四氯丙烯

密度：

1.539g/cm3

熔点：

29-31 °C(lit.)

沸点：

173.8ºC at 760mmHg

闪点：

62.3ºC

折射率：

1.512

蒸汽压：

1.66mmHg at 25°C

存储条件/存储方法：

储存注意事项^[12]  储存于阴凉、通风的库房。远离火种、热源。保持容器密封。应与氧化剂、碱类、活性金属粉末、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。

稳定性相关：

1.稳定性^[7]   稳定

2.禁配物^[8]   强氧化剂、强碱、钾、钠

3.避免接触的条件^[9]   受热

4.聚合危害^[10]   聚合

5.分解产物^[11]  氯化氢

其它信息：

1.性状：无色、透明液体，工业品常呈棕黄色。^[1]

2.沸点（℃）：167.1^[2]

3.相对密度（水=1）：1.55（20℃）^[3]

4.溶解性：微溶于水。^[4]

海关代码：

29333999

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R37/38:Irritating to respiratory system and skin . R41:Risk of serious damage to eyes. R36/37/38:Irritating to eyes, respiratory system and skin . R34:Causes burns.

安全说明：

S26-S37/39

危险标志：

Xi,C

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UD1925000

CHEMICAL NAME :

Propene, 1,1,2,3-tetrachloro-

CAS REGISTRY NUMBER :

10436-39-2

BEILSTEIN REFERENCE NO. :

1744014

LAST UPDATED :

199712

DATA ITEMS CITED :

21

MOLECULAR FORMULA :

C3-H2-Cl4

MOLECULAR WEIGHT :

179.85

WISWESSER LINE NOTATION :

GYGUYG1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

350 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1500 mg/m3

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

800 mg/kg

TOXIC EFFECTS :

Liver - other changes

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3200 mg/m3

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

477 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

400 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

910 mg/kg/26W-I

TOXIC EFFECTS :

Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

400 ug/m3/24H/13W-I

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Behavioral - alteration of classical conditioning

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

11 mg/m3/4H/17W-I

TOXIC EFFECTS :

Behavioral - alteration of classical conditioning

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

5 ppm/6H

SEX/DURATION :

female 10 week(s) pre-mating female 1-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :

Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Ovary

DOSE/DURATION :

200 umol/L

REFERENCE :

CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959- Volume(issue)/page/year: 23,17,1981

毒理学数据：

1.急性毒性^[5]

LD50：3.73ml（5632.3mg）/kg（兔经皮）

LC50：1500mg/m³（大鼠吸入）；3000mg/m³（小鼠吸入）

2.刺激性  暂无资料

3.致突变性^[6]  微生物致突变：鼠伤寒沙门菌10μg/皿。细胞遗传学分析：仓鼠卵巢100μmol/L。姐妹染色单体交换：仓鼠卵巢200μmol/L。

 

生态数据：

1.生态毒性  暂无资料

2.生物降解性  暂无资料

3.非生物降解性  暂无资料

 

分子结构数据

1、摩尔折射率：35.08

2、摩尔体积（cm³/mol）：116.8

3、等张比容（90.2K）：284.8

4、表面张力（dyne/cm）：35.3

5、极化率（10-24cm3）：13.90

计算化学数据

1.疏水参数计算参考值（XlogP）:3

2.氢键供体数量:0

3.氢键受体数量:0

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:7

8.表面电荷:0

9.复杂度:80.9

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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