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泼尼莫司汀 基本信息
- 中文名称：
- 泼尼莫司汀
- 中文别名：
- 泼尼莫司汀
- 英文名称：
- [2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoate
- 英文别名：
- prednimustine;
precorrin-6y;
3,7,12,17-Corrintetrapropanoic acid,2,8,13,18-tetrakis(carboxymethyl)-7,8,11,12-tetradehydro-9,10,11,22-tetrahydro-3,9,13,18,19-pentamethyl-,(1R-(1alpha,2alpha,3beta,9beta,13alpha,17beta,18alpha,19beta))
- CAS No.：
- 29069-24-7
- 分 子 式：
- C35H45Cl2NO6
- 分 子 量：
- 646.6409
- 精确分子量：
- 645.26200
- PSA：
- 104.14000
- InChI：
- The Key: HFVNWDWLWUCIHC-GUPDPFMOSA-N
- 分子结构式：
-
- SDS：
- 查看
泼尼莫司汀 物化性质
- 密度：
- 1.3g/cm3
- 熔点：
- 163-164ºC
- 沸点：
- 791.5ºC at 760 mmHg
- 闪点：
- 432.5ºC
- 折射率：
- 1.606
- 蒸汽压：
- 2.08E-26mmHg at 25°C
泼尼莫司汀 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4153000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione,
11-beta,17,21-trihydroxy-,
21-(4-(p-(bis(2-chloroethyl)amino) phenyl)butyrate)
- CAS REGISTRY NUMBER :
- 29069-24-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C35-H45-Cl2-N-O6
- MOLECULAR WEIGHT :
- 646.71
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV3R DN2G2G& FQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 16 mg/kg/4W
- TOXIC EFFECTS :
- Behavioral - euphoria
Blood - leukopenia
Blood - thrombocytopenia
- REFERENCE :
- JNMDBO Journal of Medicine (Westbury, NY). (PJD Pub., Ltd., POB 966,
Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 8,115,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 530 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
1,137,1976
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 128 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981. For
publisher information, see EJCODS. Volume(issue)/page/year: 13,873,1977
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 128 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981. For
publisher information, see EJCODS. Volume(issue)/page/year: 13,873,1977
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 50,115,1990
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 50,115,1990
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 50,115,1990
