溴化钠

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

溴化钠 基本信息

中文名称:
溴化钠 
中文别名:
溴化钠;
钠臭 
英文名称:
Sodium bromide
英文别名:
sodium bromide;
Sodiumbomide;
sodiium bromide;
NaBr;
sodium boron;
Sodum bromide;
Sedoneural;
sodium bromine;
bromnatrium;
Natriumbromid;
SODIUM BROMID;
bromuredesodium 
CAS No.:
7647-15-6
分 子 式:
NaBr
分 子 量:
102.89
精确分子量:
101.90800
PSA:
0.00000
MDL:
MFCD00003475
EINECS:
231-599-9
InChI:
InChI=1/BrH.Na/h1H;/q;+1/p-1
危险品标志:
IrritantXi
风险术语:
R36/37/38
安全术语:
S24/25;S25;S26;S36
分子结构式:
SDS:
查看

溴化钠 制备方法及用途

制备方法

尿素还原法将纯碱(碳酸钠)、尿素用热水溶解,并送入反应器中,缓慢加入溴素进行反应,生成溴化钠。然后再加入活性炭脱色,经过滤、蒸发结晶、离心分离、干燥,制得溴化钠成品。其反应方程式如下:中和法将约40%的氢溴酸加入反应器中,在搅拌下缓慢加入40%烧碱溶液进行中和,至Ph7.5~8时生成溴化钠,经离心分离、蒸发、结晶再离心分离,制得溴化钠成品。其反应方程式如下:3.碳酸钠、尿素用热水溶解,通入溴素,还原生成溴化钠,然后加入活性炭脱色、过滤、蒸发、结晶即得。4.将碳酸氢钠慢慢加到氢溴酸溶液中进行中和反应:加热赶出二氧化碳气体并浓缩溶液至结晶,然后冷却至室温,析出的结晶用少量水溶解,并滴加溴水至刚出现溴的颜色,加入硫化氢溶液进行脱色,加热蒸发浓缩结晶至干,高温析出无水溴化物。110℃下保温干燥后在保干器中冷却,即得无水溴化物。

合成制备方法

尿素还原法

用途简介

用于制造照相胶片感光乳剂,在医药工业用于生产药物中间体,如利尿剂,镇静剂等,也用于合成材料和合成染料作溴化剂。

用途

1.感光工业用于配制胶片感光液。医药上用于生产利尿剂和镇静剂。香料工业中用于生产合成香料。印染工业中用作溴化剂。此外,还用于有机合成等方面

溴化钠 物化性质

外观与性状:
白色粉末
密度:
3,203 g/cm3
熔点:
755 °C(lit.)
沸点:
1390 °C
闪点:
1390°C
水溶解性:
905 g/L (20 ºC)
折射率:
1.6412
存储条件/存储方法:
库房低温,通风,干燥
稳定性相关:

1.在空气中有吸湿性。易溶于水(100 ℃时溶解度为121 g/100 ml水),水溶液呈中性。微溶于醇。51 ℃时溶液中析出无水溴化钠结晶,低于51 ℃则生成二水物。其溴离子可被氟、氯所取代。在酸性条件下,能被氧氧化,游离出溴。可与稀硫酸反应生成溴化氢。
2.在酸性条件下,能被氧氧化,游离出溴。可与稀硫酸反应生成溴化氢。工作人员应作好防护,若不慎触及眼睛,应立即用大量流动清水冲洗。工作环境应具有良好的通风条件。

其它信息:

1.性状:无色立方晶系晶体或白色颗粒状粉末。无臭,味咸而微苦。

溴化钠 安全信息

海关代码:
2827510000
WGK_Germany:
1
德国有关水污染物质的分类清单
危险类别码:
R36/37/38
安全说明:
S24/25-S25
RTECS号:
VZ3150000
安全标志:
S24/25:防止皮肤和眼睛接触。
危险标志:
Xi: Irritant;

溴化钠 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VZ3150000
CHEMICAL NAME :
Sodium bromide
CAS REGISTRY NUMBER :
7647-15-6
LAST UPDATED :
199710
DATA ITEMS CITED :
23
MOLECULAR FORMULA :
Br-Na
MOLECULAR WEIGHT :
102.90
WISWESSER LINE NOTATION :
NA E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 55,200,1935
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Skin and Appendages - hair
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56,377,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 85,305,1955
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,391,1950
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5020 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 50,858,1961
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,243,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
104 gm/kg/90D-C
TOXIC EFFECTS :
Endocrine - thyroid weight (goiter) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 2,257,1974
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3150 mg/kg/6W-C
TOXIC EFFECTS :
Endocrine - evidence of thyroid hyperfunction
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,383,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1172 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(1),13,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15960 mg/kg/2W-I
TOXIC EFFECTS :
Endocrine - thyroid weight (goiter) Endocrine - changes in thyroid weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 12,93,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
538 gm/kg/4W-C
TOXIC EFFECTS :
Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,391,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46656 mg/kg/36D-C
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,405,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
23439 ug/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(1),13,1972 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
47520 mg/kg
SEX/DURATION :
male 90 day(s) pre-mating female 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,383,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3600 mg/kg
SEX/DURATION :
female 3-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,215,1944
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
720 mg/kg
SEX/DURATION :
female 3-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
JOPSAM Journal of Psychology. (Journal Press, 2 Commercial St., Provincetown, MA 02657) V.1- 1935/36- Volume(issue)/page/year: 19,17,1945
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1620 mg/kg
SEX/DURATION :
male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,383,1983 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83904 No. of Facilities: 3418 (estimated) No. of Industries: 28 No. of Occupations: 23 No. of Employees: 20436 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83904 No. of Facilities: 11062 (estimated) No. of Industries: 87 No. of Occupations: 65 No. of Employees: 124815 (estimated) No. of Female Employees: 45219 (estimated)
毒理学数据:

急性毒性:LD50:7000mg/Kg(大鼠经口);3500mg/Kg(兔经皮)
生态数据:

水危害级别1:对水是稍微危害的,不要让未稀释或大量的产品接触地下水,水道或者污水系统。

溴化钠 MSDS

Name: Sodium bromide p.a. Material Safety Data Sheet
Synonym: Bromide salt of sodium, Sedoneura
CAS: 7647-15-6
Section 1 - Chemical Product   MSDS Name:Sodium bromide p.a. Material Safety Data Sheet
Synonym:Bromide salt of sodium, Sedoneura

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
7647-15-6 Sodiumbromide 100% 231-599-9
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Hygroscopic.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Effects may be cumulative. May cause central nervous system effects such as psychosis, hallucinations, depression, visual changes and mental changes. Ingestion may cause skin eruptions and rash.
Inhalation:
May cause effects similar to those described for ingestion.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause incoordination and mental disturbances.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician:
Treatment includes hydration, mild diuresis, and possible hemodialysis. Consider the use of ammonium chloride in divided doses with a diuretic.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Substance is noncombustible.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear a chemical apron.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Solid
Appearance: white
Odor: Odorless
pH: 6.5-8.0
Vapor Pressure: 1 mm Hg @ 806 deg C
Viscosity: Not available.
Boiling Point: 1390 deg C @ 760.00mm Hg
Freezing/Melting Point: 755 deg C
Autoignition Temperature: Not available.
Flash Point: 800 deg C ( 1,472.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 800 deg C
Solubility in water: 95g/100ml water (25 c)
Specific Gravity/Density: 3.21g/cm3
Molecular Formula: BrNa
Molecular Weight: 102.8938

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, heating to decomposition, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong acids - alkaloidal and heavy metal salts (lead, silver, manganese, antimony, mercury, etc.) - strong oxidizing agents - halogen halides - bromine trifluoride.
Hazardous Decomposition Products:
Hydrogen bromide, sodium oxide, bromine fumes.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 7647-15-6: VZ3150000 LD50/LC50:
CAS# 7647-15-6: Oral, mouse: LD50 = 7 gm/kg; Oral, rat: LD50 = 3500 mg/kg.
Carcinogenicity:
Sodiumbromide - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Water danger/protection: WGK 1 Bluegill sunfish LC50: >1000 mg/l/96H Rainbow trout LC50: >1000 mg/l/96H Daphnia magna LC50: >1000 mg/l/48H Bobwhite quail LD50: >2250 mg/kg Mallard duck LC50: >5633 ppm Bobwhite quail LC50: >5633 ppm

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Shipping Name: Not regulated.
Dangerous Goods Code:
UN Number:

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 7647-15-6: 1
United Kingdom Occupational Exposure Limits
Canada
CAS# 7647-15-6 is listed on Canada's DSL List.
CAS# 7647-15-6 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 7647-15-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

溴化钠 分子结构与计算化学数据

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:2

8.表面电荷:0

9.复杂度:2

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2

溴化钠 上游产品

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溴化钠 表征图谱

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湖北军瑞生物科技有限公司

产品介绍:
产品名称:溴化钠 Cas号:7647-15-6 纯度:99% 包装信息:200镀锌铁桶/塑料桶kg,25纸板桶/编织袋/塑料桶kg,10铝听/纸箱kg,1铝箔袋/氟化瓶kg 价格:1.0元 - 25.0元
联系方式:
联系人:向 电话:13971166412 手机:13971166412

南京化学试剂股份有限公司

产品介绍:
产品名称:溴化钠 Cas号:7647-15-6 纯度:99.0% 包装信息:500g 价格:洽谈
联系方式:
联系人:南试 电话:025-58369808 手机:13813995600

上海吉至生化科技有限公司

产品介绍:
产品名称:溴化钠 Cas号:7647-15-6 纯度:99% 包装信息:500gea 价格:78.0元
联系方式:
联系人:江珊 电话:021-57520831 手机:15316869680

上海斯迈克贸易有限公司

产品介绍:
产品名称:溴化钠 Cas号:7647-15-6 纯度:≥99% 包装信息:1000kgs/bulkbag,25kgs/bag袋 价格:洽谈
联系方式:
联系人:袁经理 电话:021-68811293 手机:

北京百灵威科技有限公司

产品介绍:
产品名称:溴化钠 926428 Cas号:7647-15-6 纯度:100% 包装信息:300g 价格:洽谈
联系方式:
联系人:翟先生 电话:18210857532 手机:18210857532